From hepatitis B to hepatitis C, she is a model female scientist in both teaching and research. Wu Lee Yan-Hwa and four Yang-Ming University professors (Ting Ling-Pai, Liu Wu-Che, Lo Shih-Cheng, Chu Kuang-Pang) jointly participated in the completion of the selection of hepatitis B virus surface antigen gene fragments and small-scale development of gene recombination for the hepatitis B vaccine. In early 1990, Wu Lee Yan-Hwa turned to hepatitis C virus research from hepatitis B and found that the core protein of the hepatitis C virus can inhibit hepatitis B virus replication, and further discovered the possible carcinogenic mechanism of the hepatitis C core protein. The follow-up team conducted in-depth research and discovered the interaction between the core protein of the hepatitis C virus and the important proteins and regulatory factors in the host cell. In addition, the team has published many outstanding results in the research of the RNA helicase DDX3 and the oncogene YB-1. .