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按鈕:01_B肝發現者hbv discoverer
按鈕:02女力當自強female scientist
按鈕:03_基礎醫學basic medicine
按鈕:04_臨床醫學clinical medicine
按鈕:05公衛推動
陳建仁/ Cheng Jian-Jen
Chen Jian-Jen is the former vice president of Taiwan. In the past, he led a team to publish a long-term 12-year follow-up research paper in 2002. He pointed out that the positive indicators of hepatitis B virus and E antigen can predict the occurrence of liver cancer. After further research, in 2006 he published that the amount of hepatitis B virus in the blood of patients is an important indicator for predicting liver cancer in the carrier. Almost all liver societies around the world have rewritten their clinical guidelines to include testing for the amount of hepatitis B virus.
Awards
2005年總統科學獎
Further Reading
2005年總統科學獎得主-陳建仁院士
https://web.most.gov.tw/SciencePrize/2019/4663635622.html
病毒與癌症
https://scitechvista.nat.gov.tw/Article/C000009/detail?ID=45856f61-6e92-4a5c-8923-09c4ece82ef6
張定宗/Chang Ting-Tsung
Chang Ting-Tsung used next-generation sequencing (NGS) to investigate the differences in the sequence performance of multiple variants of the hepatitis B virus in the blood serum and liver tissues of patients with liver cancer caused by hepatitis B virus infection and those patients with chronic hepatitis B before and after treatment.
Awards
科技部傑出研究獎(獲獎2次)
Tao Mi-Hua clarified the immune tolerance mechanism existent in chronic hepatitis B virus infections and tumor microenvironments. He also developed treatment methods to overcome immune tolerance, reactivation of specific immunity for viruses and tumors, and other methods to achieve the elimination of the hepatitis B virus, liver cancer, and other cancers.
Awards
科技部傑出研究獎(獲獎2次)
張仲明/ Zhang Zhong-Ming
Chang Chung-Ming is currently an Investigator Emeritus of the National Health Research Institutes. He is researching the mechanisms of cytokine-mediated inhibition of viral replication and the synergistic relationship with chronic hepatitis to search for new methods of curing chronic hepatitis B. Chang Chung-Ming was the five-time recipient of the Outstanding Research Award, Ministry of Science and Technology.
Awards
科技部傑出研究獎(獲獎3次)
Further Reading
過去生醫獎精彩案例
https://scitechvista.nat.gov.tw/Article/C000008/detail?ID=e7dff7f8-b450-4c46-adf2-e3acc1905dc9
蔡忠佑/ Tsai Tsung-yu
Dr. Tsai Tsung-Yu discovered the Siglec-3 immune-checkpoint and found a new method for treating chronic hepatitis B infections. This breakthrough is able to breathe new life into the stagnated research of hepatitis B treatment. Dr. Tsai Tsung-Yu together with the team from Academia Sinica, discovered that the surface antigen of the hepatitis B virus (HBsAg) contains sialoglycans that will combine with the Siglec-3 immune-checkpoint on immune cells to suppress the ability of the immune system to fight viruses. During the process of research, the team explored how the hepatitis B virus suppressed the immune system. Using the immune cells from the blood of chronic hepatitis B patients, it was proven that the Siglec-3 antibody is able to disrupt the connection of hepatitis B and Siglec-3. As a result, the patient’s immune system is able to be activated. This research was published in an international paper on June 1, 2021.
Further Reading
根治慢性B肝現曙光:Siglec-3 (CD33)是B肝病毒的免疫檢查點
https://www.genomics.sinica.edu.tw/index.php/tw/news/lastest-news/661-b-siglec-3-cd33
Chou Chen-Kung researched the complicated interactions between the hepatitis B virus and the immune system. Through this research, he was able to better understand how the virus could potentially result in liver cancer. By integrating the DNA microarray and gene expression profiles of the two different mouse models (liver regeneration and hepatitis B surface antigen in transgenic mice), Chou was able to spot the differences and similarities in the two models and the possibility of epigenetic regulation.
Awards
科技部傑出研究獎(獲獎3次)
Further Reading
過去生醫獎精彩案例
https://scitechvista.nat.gov.tw/Article/C000008/detail?ID=e7dff7f8-b450-4c46-adf2-e3acc1905dc9
曾岱宗/ Tseng Tai-Chung
Dr. Tseng Tai-Chung is dedicated in his research of hepatitis B virus related clinical and basic research. His application of surface antigen was even used as a clinical practice guideline by the American Association for the Study of Liver Diseases (AASLD). In recent years, Dr. Tseng is actively exploring using next generation sequencing to investigate the correlation between the hepatitis B virus genome, disease progression, and immunity. Tseng also developed a mouse model for hepatitis B related liver cancer and is now exploring the possibility of using immunotherapy to cure hepatitis B related diseases.
Awards
科技部傑出研究獎
Further Reading
年輕優秀研究 - 曾岱宗醫師
https://www.ntuh.gov.tw/LARD/News.action?q_type=-1&q_itemCode=6445&agroup=c
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