陳明汝 Ming-Ju Chen

Research on traditional fermented milks reveals microbial communication and biosynthesis

My research program significantly advances the field of microbiology by translating fundamental discoveries into impactful health applications and commercial successes. My work focuses on the previously under-explored area of traditional fermented milk starters, bridging fundamental scientific understanding with impactful technological advancements.

Fundamental research has elucidated the intricate communication and biosynthesis pathways within kefir grains and related products. A key achievement is the successful biosynthesis of kefir grains using pure cultures, overcoming a significant field limitation. These researches, employing advanced omics and quorum sensing techniques, have yielded eight high-impact publications and extensive citations, establishing its significant scientific influence and providing a strong foundation for subsequent applied research and commercialization (Figure 1).

This foundation has led to substantial applied research translating discoveries into real-world benefits. The development of postbiotics using Lactobacillus kefiranofaciens M1 has resulted in over 20 globally marketed products. Furthermore, pioneering research on precision probiotics targeting chronic kidney disease (CKD) via the gut-kidney axis represents a notable advance in precision medicine. The promising results from research on Lactobacillus mali APS1 for combating obesity and metabolic syndrome further demonstrate the potential for broad health impact. The significant commercial success, including technology transfer exceeding NT$10 million and product market value exceeding NT$200 million, underscores the high impact and commercial viability of this research. The consistent generation of high-impact publications, coupled with tangible commercial success and positive clinical outcomes, firmly establishes my leadership within the field.