2016 ANNUAL REVIEW Ministry of Science and Technology

typhoons and strong convection centers, which will improve the accuracy of typhoon track forecasting and disaster relief decision-making. NARLabs has developed Lidar wind profiler measurement and data analysis technology that can be applied in the development of offshore wind power; this project using weather/sea condition observation tower data and environmental data in value-added interactive analysis, has completed observations during the northeast and southwest monsoons, and has analyzed wind speed profile and the characteristics of atmospheric turbulence, which will provide reference information needed in the assessment of wind power and drafting of wind turbine specifications. NARLabs' researchers are performing real-time monitoring of water temperature, salinity, depth, turbidity, pressure, and flow velocity, etc., using image analysis to observe marine organisms and environments, and are employing configurable carrier platforms to collect deep-sea water, which will facilitate real- time analysis of undersea data. The domestically- produced FORMOSAT-5 satellite includes an optical remote sensing payload, which is the first of its kind to be 100% manufactured in Taiwan through the joint efforts of industry, universities, and research units. After the satellite has entered orbit, it will acquire high-resolution images of the Earth that can be used in government and civilian applications spanning the areas of homeland security, environmental monitoring, disaster prevention and assessment, and scientific research. 2. Information and Communications Technology NARLabs developed Internet protocol (IP) technology for CMOS (Complementary Metal-Oxide- Semiconductor) sensors. This technology can be used in flexible combinations of chips or system packaging, and can accelerate the realization of sensing system chips meeting the needs of wearable and Internet of Things devices. Energy management chips developed by NARLabs can acquire electric energy from energy sources as small as vibrations and as large as solar power; these chips can be incorporated in various green energy applications, and can be used in various kinds of wearable or Internet of Things systems. Researchers successfully developed a "subcutaneous blood clot imaging system" able to perform comprehensive, full-scale identification of subcutaneous blood clots during the initial period after an injury; a cooperating firm has realized a product based on this system that can be used to perform investigation and obtain evidence in criminal cases. NARLabs researchers working in conjunction with the Taiwan Semiconductor Manufacturing Co. (TSMC) successfully developed a 12" plasma-enhanced atomic layer deposition (PEALD) system able to boost plasma response efficiency and achieve superior film quality on 12" silicon wafers. The newly-developed cloud-based Cyber Defense Exercise Workshop is able to provide a setting for attack/defense exercises, and its ability to mimic a corporate network environment allows information security personnel to research attack and defense techniques. Researchers applying image analysis and machine learning have developed monitoring and big data integration technology, including automated traffic monitoring and identification and automated bad weather water situation image correction and flooding forecasting systems; the former can facilitate the collection of intersection vehicle traffic and type data, while the latter can assist monitoring of water conditions and forecast flooding, which will allow the two technologies to make contributions to smart transportation and smart disaster prevention applications. 3. Biomedical Technology Platforms NARLabs established a laboratory animal facility quality improvement assistance team, obtained international quality standard certification standards and experience from the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC), helped domestic laboratory animal facilities to improve their animal care and testing quality, obtained international certification, and helped smooth the way for Taiwan's biomedical products to enter international markets. Researchers used 3D metal printing equipment to produce Taiwan's first 3D printed artificial joint products, which have passed strict ISO-10993 biocompatibility certification and entered the international market. A "mouse neurodegenerative disease behavior analysis platform" was used to observe and record the behavior of mice, and can be applied to the preclinical testing of new drugs for degenerative diseases of the central nervous system, such as Parkinson's disease and Alzheimer's disease. A project used advanced gene editing technology to produce lipoprotein gene knock-out mice, which can be used for preclinical testing of new drugs for cardiovascular disease induced by hyperlipidemia; this breakthrough will speed the ongoing development by industrial and academic researchers of new drugs against conditions that currently cannot be treated effectively with drugs, such as cardiovascular disease and stroke. In a global first, researchers using large-fragment BAC genetic recombinant technology discovered a new gene causing polycystic kidney disease—Wdr19, which will provide new opportunities to cure polycystic kidney disease, which is a familial hereditary condition. Support for Academic Research Ministry of Science and Technology 59