{"id":5875,"date":"2021-12-20T19:11:43","date_gmt":"2021-12-20T11:11:43","guid":{"rendered":"https:\/\/www.hbv-vaccine40.tw\/history\/"},"modified":"2022-01-17T23:11:42","modified_gmt":"2022-01-17T15:11:42","slug":"history_page","status":"publish","type":"page","link":"https:\/\/www.hbv-vaccine40.tw\/en\/history_page\/","title":{"rendered":"History"},"content":{"rendered":"\t\t
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The world's hepatitis B carrier rate is 5%.\nBefore 1984, 70-80% of Taiwanese had been infected with hepatitis B, and 15-20% were permanent chronic carriers, which made the cirrhosis and liver cancer caused by viral hepatitis become Taiwanese The leading cause of death.\n<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The world's hepatitis B carrier rate is 5%.\nBefore 1984, 70-80% of Taiwanese had been infected with hepatitis B, and 15-20% were permanent chronic carriers, which made the cirrhosis and liver cancer caused by viral hepatitis become Taiwanese The leading cause of death.\n<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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1981-1990<\/div><\/div><\/div>
1991-2021<\/div><\/div><\/div>\t\t\t<\/div>\n\t\t\t
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1947<\/div><\/div>
Hepatitis is named after the route of transmission Infectious-Hepatitis A Serum-hepatitis B<\/h5>
Dr. F. O. MacCallum<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1947<\/div><\/div><\/div>
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1965<\/div><\/div>
Identified the antigen (Au) for hepatitis B in the blood of an Australian aborigine.<\/h5>
Dr. Baruch Samuel Blumberg<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1965<\/div><\/div><\/div>
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1968<\/div><\/div>
Confirmed that blood transfusion infection and Australian antigen are the culprits of hepatitis B.<\/h5>
Dr. Alfred Prince<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1968<\/div><\/div><\/div>
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1968\u5e74<\/div><\/div>
It is found that about 17% of military males in Taiwan have liver B antigen.<\/h5>
Dr. SUNG, JUEI-LOW (\u5b8b\u745e\u6a13) <\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1968\u5e74<\/div><\/div><\/div>
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1970<\/div><\/div>
Complete hepatitis B virus particles observed<\/h5>
Dr. D.S Dane<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1970<\/div><\/div><\/div>
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1971<\/div><\/div>
Obtained a patent for hepatitis B plasma vaccine.<\/h5>
Dr. Baruch Samuel Blumberg<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1971<\/div><\/div><\/div>
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1971<\/div><\/div>
Confirmed that hepatitis B causes liver cancer.<\/h5>
Dr. LUO,KUANG-RUI (\u7f85\u5149\u745e)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1971<\/div><\/div><\/div>
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1972\u5e74<\/div><\/div>
Taiwan-U.S. Cooperative Research on the Hypothesis of Mother-child Vertical Infection of Hepatitis B.<\/h5>
Dr. R. Palmer Beasley<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1972\u5e74<\/div><\/div><\/div>
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1974<\/div><\/div>
Taiwan detects hepatitis B surface antigen in blood donor serum.<\/h5>
Taiwan<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1974<\/div><\/div><\/div>
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1975<\/div><\/div>
Confirmed that hepatitis B is infected vertically through mother and child.<\/h5>
Dr. Robert Palmer Beasley<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1975<\/div><\/div><\/div>
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1976<\/div><\/div>
Proved that there is a causal relationship between hepatitis and liver cancer.<\/h5>
Dr. Robert Palmer Beasley<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1976<\/div><\/div><\/div>
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1979<\/div><\/div>
The selection and sequencing of the hepatitis B virus gene has been completed.<\/h5>
\nRecombinant replication through cloning technology<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1979<\/div><\/div><\/div>
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1980\/10<\/div><\/div>
The Department of Health of the Executive Yuan established the \"Hepatitis Prevention Committee\"<\/h5>
Department of Health<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1981<\/div><\/div>
The first hepatitis B vaccine was launched.<\/h5>
Merck
Maurice Hilleman<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1981<\/div><\/div><\/div>
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1981<\/div><\/div>
The Executive Yuan approves the \"Phase 1 Plan to Strengthen Hepatitis B Prevention and Control\"<\/h5>
Executive Yuan<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1981<\/div><\/div><\/div>
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1981\/11<\/div><\/div>
Unanimously through Taiwan,<\/span> clinical trials of hepatitis B vaccine<\/span> are required<\/span>\u3002<\/h5>
Assembling clinical trial experts from the US, UK, France, and Japan, including Pasteur and Merck Pharmaceuticals.<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1981\/11<\/div><\/div><\/div>
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1981<\/div><\/div>
National Taiwan University and Taipei President Wing conducted research on newborns of hepatitis B surrogate mothers.<\/h5>
Dr. Robert Palmer Beasley,
\nDr. LUO, KUANG-RUI (\u7f85\u5149\u745e)<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1981<\/div><\/div><\/div>
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1982<\/div><\/div>
The National Science Council of Taiwan participates in the negotiation of commercial transfer of hepatitis B vaccine.<\/h5>
National Science Council
Dr. TIAN, WEI-CHENG (\u7530\u851a\u57ce)<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1982<\/div><\/div><\/div>
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1983\/3\/28<\/div><\/div>
The Executive Yuan approved the \"Hepatitis B Vaccination Program.\"<\/h5>
Executive Yuan<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1983\/3\/28<\/div><\/div><\/div>
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1983\/8<\/div><\/div>
The Executive Yuan has adopted the science and technology development plan to list hepatitis<\/h5>
Executive Yuan
National Science Council<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1983\/8<\/div><\/div><\/div>
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1983\/11<\/div><\/div>
prevention and treatment as one of the eight key technologies.<\/h5>
Department of Health<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1983\/11<\/div><\/div><\/div>
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1984<\/div><\/div>
Infants born to pregnant women with hepatitis B are given full hepatitis B vaccine.<\/h5>
Taiwan<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1984<\/div><\/div><\/div>
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1985<\/div><\/div>
The selection and sequencing of the Taiwanese hepatitis B virus gene has been completed.<\/h5>
Dr. Y.-H. Wu(\u5433\u598d\u83ef),
Yang Ming University Group of Five<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1985<\/div><\/div><\/div>
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1985<\/div><\/div>
Propose the definition of the natural course of chronic hepatitis B.<\/h5>
Dr. LIAW, YUN-FAN(\u5ed6\u904b\u7bc4)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1985<\/div><\/div><\/div>
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1986\/7<\/div><\/div>
All newborns receive free hepatitis B vaccine.<\/h5>
Taiwan<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1986\/7<\/div><\/div><\/div>
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1986<\/div><\/div>
Transgenic yeast hepatitis B vaccine launched.<\/h5>
Taiwan<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1986<\/div><\/div><\/div>
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1987<\/div><\/div>
Production of HBV particles in vitro by transfection of cloned HBVDNA to well-differentiated hepatoma cell lines. Chang.<\/h5>
Dr. CHANG, CHUNG-MING (\u5f35\u4ef2\u660e)<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1987<\/div><\/div><\/div>
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1987<\/div><\/div>
From July onwards, the hepatitis B plasma vaccine
from Baosheng Company was used.<\/span><\/h5>
Executive Yuan<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1987<\/div><\/div><\/div>
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1989<\/div><\/div>
Engerix-B listed.<\/h5>
International<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1989<\/div><\/div><\/div>
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1989<\/div><\/div>
A Hepatitis B virus transcript produced by the RNA splicing mechanism.<\/h5>
Dr. Su TS (\u8607\u5b97\u7b19)<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1989<\/div><\/div><\/div>
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1990<\/div><\/div>
Identification of the genome of hepatitis B virus contains a second enhancer cooperation of two elements within this enhancer is required for its function.<\/h5>
Dr. Ting LP (\u4e01\u4ee4\u767d)<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\"\u535a\u58eb\u5a03\u5a03\u7d20\u6750\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>
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<\/div><\/div>\n\t
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1993<\/div><\/div>
Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells.<\/h5>
Dr. Y.-H. Wu (\u5433\u598d\u83ef)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
<\/div>\n\t<\/div>\n\t
<\/i><\/span><\/div><\/div>
1993<\/div><\/div><\/div>
\n\t
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1997<\/div><\/div>
Hepatitis B vaccine prophylaxis effectively reduces the incidence of liver cancer in children<\/h5>
Dr. CHANG, MEI-HWEI (\u5f35\u7f8e\u60e0)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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1997<\/div><\/div><\/div>
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2002<\/div><\/div>
The positive index of hepatitis B virus E antigen predicts the incidence of liver cancer.<\/h5>
Dr. CHEN, JIAN-JEN (\u9673\u5efa\u4ec1),
Dr. YANG, HWAI-I (\u694a\u61f7\u58f9)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
<\/div>\n\t<\/div>\n\t
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2002<\/div><\/div><\/div>
\n\t
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2005<\/div><\/div>
Confirmed that hepatitis B vaccine
can effectively prevent cancer.<\/span><\/h5>
Dr. CHANG, MEI-HWEI (\u5f35\u7f8e\u60e0)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
<\/div>\n\t<\/div>\n\t
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2005<\/div><\/div><\/div>
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2009<\/div><\/div>
Extend the payment period of medical health insurance treatment for patients with chronic hepatitis B.<\/h5>
Ministry of Health and Welfare<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
<\/div>\n\t<\/div>\n\t
<\/i><\/span><\/div><\/div>
2009<\/div><\/div><\/div>
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2011<\/div><\/div>
Role of Hepatitis B Surface Antigen Level in Long-term Outcomes of Hospital-based Hepatitis B Virus Carriers.<\/h5>
Dr. TSENG, TAI-CHUNG (\u66fe\u5cb1\u5b97)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
<\/div>\n\t<\/div>\n\t
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2011<\/div><\/div><\/div>
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2016<\/div><\/div>
Sorafenib inhibits hepatitis B virus X activated oncogenic androgen pathway in liver through SHP-1.<\/h5>
Dr. Yeh SH (\u8449\u79c0\u6167)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
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2016<\/div><\/div><\/div>
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2017<\/div><\/div>
Heplisav-B vaccine approved by the U.S. FDA.<\/h5>
International<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
<\/div>\n\t<\/div>\n\t
<\/i><\/span><\/div><\/div>
2017<\/div><\/div><\/div>
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2021<\/div><\/div>
IGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection.<\/h5>
Dr. Tsai TY(\u8521\u5b97\u4f51)<\/div>
more<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t
<\/div>\n\t<\/div>\n\t
<\/i><\/span><\/div><\/div>
2021<\/div><\/div><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\"\u535a\u58eb\u5a03\u5a03\u7d20\u6750\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\"\u535a\u58eb\u5a03\u5a03\u7d20\u6750\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t
<\/div>\n\t\t
\n\t\t\t<\/i><\/span>Home<\/span>\t\t<\/div>\n\t\t
\n\t\t\tGo<\/span>\t\t<\/div>\n\t<\/a>\n<\/div>\n<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

The world’s hepatitis B carrier rate is 5%. Before 1984, 70-80% of Taiwanese had been infected with hepatitis B, and 15-20% were permanent chronic carriers, which made the cirrhosis and liver cancer caused by viral hepatitis become Taiwanese The leading cause of death. The world’s hepatitis B carrier rate is 5%. Before 1984, 70-80% of […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":[],"_links":{"self":[{"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/pages\/5875"}],"collection":[{"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/comments?post=5875"}],"version-history":[{"count":7,"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/pages\/5875\/revisions"}],"predecessor-version":[{"id":6051,"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/pages\/5875\/revisions\/6051"}],"wp:attachment":[{"href":"https:\/\/www.hbv-vaccine40.tw\/en\/wp-json\/wp\/v2\/media?parent=5875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}