胡哲銘 Che-Ming Jack Hu

創新奈米技術及生物材料 用於抗病毒和免疫工程

My research focuses on the development of novel delivery nanotechnologies and functional biomaterials for infectious disease treatments and immune system modulation. The research topics can be divided into four categories..

The first category includes the development of novel nanotechnologies for antiviral drug delivery and virus diagnostics. I developed antiviral nanomedicines that tackle host factors responsible for viral infections, and a magnetic nanoparticle coated in cell membranes that enhances the detection sensitivity of viral pathogens.

The second category involves enhancing antibiotics selectivity by nanocoacervation. Through colistin nanocoacervation, I was able to minimize colistin's interaction with cellular membranes while retaining its activity against bacteria.

The third category involves development of novel vaccine technologies against viral and oncological diseases. I pioneered an artificial hollow polymeric nanoparticle that bears striking morphological semblance to virus capsids and can be engineered to make safe and effective vaccines.

Lastly, I invented a cell-derived, hydrogel based approach for artificial antigen presenting cell development , which enhances the proliferation of T cells and can be used to engineer immunotherapies. The majority of the research has a translational aspect with broad public health implication, and they also show fundamental mechanistic insights at the material and biology interface. The studies provide new insights into emulsion techniques, liquid-liquid phase separation, and the molecular dynamics of peptide delivery, and they have the potential to revolutionize the field of infectious disease management and immunotherapy.

得獎感言

I am deeply honored to receive the Outstanding Research Award from the National Science and Technology Council. This award is a recognition of the hard work and dedication of my research team, collaborators, and mentors, who made invaluable contributions to my academic journey. My research has focused on the development of novel delivery nanotechnologies and functional biomaterials for infectious disease treatments and immune system modulation. Through this work, I hope to make a positive impact on global public health by providing new and innovative solutions to some of the most pressing biomedical challenges facing society today. The unique, multidisciplinary nature of my research constantly thrusts me into new topics in nanotechnology, immunology, virology, and cancer biology. While they can be daunting at times, the constant streams of new information often makes me feel like a kid in a candy shop, and I am grateful and enthused to be in a position that deep into my adulthood I can still be learning and asking questions like a school-age child. I feel incredibly blessed to have the facilities, support, and co-workers to indulge my curiosity and chase my passion, and receiving this award further reinforces my commitment, providing me the strength and encouragement to overcome those inevitable flickering moments of doubts in the long journey of academic pursuit. I am deeply grateful for this recognition.